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KMID : 0382619850050020433
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Hanyang Journal of Medicine
1985 Volume.5 No. 2 p.433 ~ p.446
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Cardiovascular Responses to Intravenously Administered Bovine Bile in Conscious Cats
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Abstract
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The present study was designed to investigate cardiovascular responses to in-travenously administered bovine bile in unanesthetized cats. Also studied were ef-fects of regitine, propranolol and atropine pretreatment on the cardiovascular responses following intravenous administration of bovine bile in conscious animals.
The results obtained from the present study were as follows;
1. One minute after 30mg/ kg bile administration the heart rate of anesthetized cats increased from 139.6 ± 4.3/min to 157.4 ± 7.6/min probably due to baroreceptor reflex.
2. In conscious cats heart rate decreased from 178.8 ± 7.4/min to 146.0 ± 10.1/min one minute after intravenous administration of bile and the decreased heart rate response persisted for 5 minutes thereafter.
3. Heart rate responses to bile were almost blocked following atropinization of conscious animals.
4. After intravenous administration of 30mg/ kg bovine bile depressor responses were observed invariably in both anesthetized (79.2 ± 3.8 mmHg) and unanesthetized cats (60.9 ± 7.6 mmHg). In general depressor response to bile was more pronounced in anesthetized animals while the recovery from decreased blood pressure was more rapid in unanesthetized cats.
5. In conscious animals, depressor responses to bovine bile were partially block-ed following regitine pretreatment, while no changes in depressor responses were noticed in either atropine or propranolol treated animals.
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